There is controversy about the effect of melatonin on seizure disorders. The most common side effect is gastric distress. Melatonin is classified by the FDA as 'generally regarded as safe' in recommended doses for short-term use. blood thinning medication such as warfarin (Coumadin),.benzodiazepines such as lorazepam (Ativan), triazolam (Halcion), or diazepam (Valium),.Special care is appropriate for people taking: Consultation with the prescribing physician is essential if any prescription drug is being taken with melatonin.

Psychotropic drugs that affect norepinephrine or serotonin levels might alter the pattern of melatonin production and that any drugs that might affect the metabolism of melatonin in the liver, such as valproic acid or methoxypsoralen, could affect blood serum levels of melatonin. Alcohol, caffeine and aspirin may affect melatonin levels. Drug Interactionsĭrug interactions with melatonin have not been sufficiently studied, but appear manageable. Risks appear manageable, but caution is appropriate since melatonin is commonly over consumed, and, absent testing, people should 'work up' to a therapeutic dose. All other potential uses remain to be studied. Melatonin is a promising treatment for jet lag and many mild to moderate sleep disorders. dealing with the side effects of treatment for schizophrenia, particularly tardive dyskinesia and weight gain,.Other suggested but unproven uses include: Uses of melatonin to treat insomnia and maintain cognitive capacity (neuroprotection) are particularly interesting but remain unresolved. However, some of the evidence is tentative, and much more study is needed. sleep disturbances in children with neuro-psychiatric disorders, and.sleep latency (delay in falling asleep) in older people.Melatonin is a promising treatment for other sleep disorders, especially:.Agency for Healthcare Research and Quality (AHRQ) questions the evidence, the five sources that deal with melatonin all recommend it for: Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone associated with sleep.

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